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Abstract #3326

Novel Dual-Tuned 31P-1H Transceiver Head Array Enables High-Resolution Whole-brain 31P MRSI for Mapping NAD+ and NADH in the Human Brain at 7T

Xin Li1, Xiao-Hong Zhu1, Hannes M. Wiesner 1, Soo Han Soon1, Matt Waks1, and Wei Chen1
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: RF Arrays & Systems, Spectroscopy, Phosphate, NAD, Brain.

Motivation: 31P MRS imaging (MRSI) at UHF offers essential phosphorous metabolites information, but requires a dedicated 1H-31P dual-frequency head coil.

Goal(s): Provide advanced 31P-1H dual-frequency head array coil for B0 shimming, brain 1H MRI and high-resolution whole-brain 31P MRSI in humans at 7T.

Approach: We demonstrated a novel head array operating at 1H and 31P frequencies without complex coil structures or passive/active coil components.

Results: The proposed 31P-1H head array demonstrates much higher 31P-SNR (5-times in peripheral and 2-times in deep brain region) compared to the TEM volume coil, showing well defined NAD+ and NADH resonance signals in 4 subjects.

Impact: The proposed 31P-1H head coil design provides excellent 1H MRI and whole-brain high-resolution 31P MRSI, making it possible to quantify and map cellular NAD+ and NADH metabolites, thereby obtaining the NAD redox status of the entire human brain at 7T.

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