Abstract #3331

Olfactory Tract BOLD fMRI using Echo Planar Time Resolved Imaging

Kathryn Lamar¹, Fuyixue Wang², Zijing Dong², Claire Murphy³, Aaron Jacobson^3,4, Ryan Barnes⁴, Conan Chen⁵, Albert Hsiao⁶, and Thomas Liu⁶

¹Bioengineering, University of California, San Diego, La Jolla, CA, United States, ²Radiology, Harvard University, Cambridge, MA, United States, ³San Diego State University, San Diego, CA, United States, ⁴University of California, San Diego, La Jolla, CA, United States, ⁵Electrical and Computer Engineeering, University of California, San Diego, La Jolla, CA, United States, ⁶Radiology, University of California, San Diego, La Jolla, CA, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Acquisition Methods, Olfactory Bulb, OlfactoryTract, Parkinson's disease, Alzheimer's disease

Motivation: The use of fMRI for assessing olfactory function has been a significant challenge due to the increased blurring and geometric distortion caused by field inhomogeneity and T2* decay.

Goal(s): We aim to minimize distortion and motion related artifacts that corrupt olfactory tract fMRI scans by utilizing an EPTI acquisition.

Approach: We will acquire activation results using both EPTI and EPI for olfactory tract regions that suffer greatly from signal dropout and distortion for N=6 healthy, volunteers.

Impact: Olfactory dysfunction is an early indicator of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease.^1-4 In this work, we utilize an acquisition technique designed to minimize fMRI artifacts to accurately assess olfactory function potentially allowing for earlier diagnosis.

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