Keywords: Muscle, Diagnosis/Prediction
Motivation: Exertional compartment syndrome (ECS) is a painful condition characterized by abnormally high muscle compartment pressures induced by exercise. The only diagnostic method is intra-compartmental pressure measurement to directly quantify pressure via needle insertion, which is a barrier to both patients and clinicians. Due to the invasiveness and lack of physicians trained for this measurement, it is often not performed, and symptoms are misdiagnosed.
Goal(s): Determine if MRI can be a non-invasive alternative to the current diagnosis procedure and better understand the pathophysiology of ECS.
Approach: Correlate quantitative DTI, IVIM, and T2 mapping biomarkers between patients with ECS and healthy controls.
Impact: This project addresses a clinical barrier preventing diagnosis of exertional compartment syndrome. We will demonstrate the potential for MRI as a non-invasive diagnostic tool and explore its underlying mechanisms to allow for informative treatment decisions and reduce barriers to diagnosis
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