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Abstract #3347

Structural and Functional Looping Star MR Neuroimaging at 7T

Florian Wiesinger1,2, Marta Lancione3, Brice Fernandez4, Ana Beatriz Solana1,2, Paolo Cecchi5,6, Laura Biagi3, Matteo Cencini5,7, Thomas Loboy Ramos1,8, Marion Menzel1,8,9, Graziella Donatelli5,6, Renzo Guerrini10,11, and Michela Tosetti3
1GE HealthCare, Munich, Germany, 2King's College London, London, United Kingdom, 3IRCCS Stella Maris Foundation, Pisa, Italy, 4GE HealthCare, Buc, France, 5IMAGO7 Foundation, Pisa, Italy, 6University of Pisa, Pisa, Italy, 7INFN Pisa Divisi, Pisa, Italy, 8TH Ingolstadt, Ingolstadt, Germany, 9TU Munich, Munich, Germany, 10Meyer Children's Hospital IRCCS, Florence, Italy, 11University of Florence, Florence, Italy

Synopsis

Keywords: New Trajectories & Spatial Encoding Methods, fMRI Acquisition, 7T, QSM, T2*, BOLD

Motivation: To establish Looping Star as a new methodology for 7T MR neuroimaging.

Goal(s): To demonstrate its feasibility and effectiveness for silent structural & functional neuroimaging and showcasing its potential to advance neuroscience research.

Approach: Looping Star, a ZTE-based multi-GRE method, was assessed on a 7T MRI scanner for both structural (1mm, five-TEs) and functional (3mm, two-TEs, 2.48 sec/volume) imaging, employing CG-SENSE to accelerate scanning while maintaining image quality.

Results: High-resolution T2* and QSM maps were obtained, with functional imaging revealing ~5% BOLD signal changes in motor areas, all while maintaining quiet acoustic noise (<5dB relative to ambient noise).

Impact: Looping Star is an innovative, new MR method for 7T neuroimaging, offering silent, 3D whole-brain multi-GRE imaging. It enables new structural and functional investigations in a quieter, more comfortable environment, ideal for advanced neuroscientific research and hyperacusis patients.

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Keywords