Keywords: New Signal Preparation Schemes, Artifacts, T1ρ relaxation, artifact compensation, quantitative imaging
Motivation: T1ρ relaxation mechanism during spin-locking is widely used for monitoring macromolecular remodeling, such as early-stage osteoarthritis. However, T1ρ measurements are sensitive to B0 and B1 magnetic field inhomogeneities.
Goal(s): To reduce artifacts in spin-locking and therefore to promote its potential for more application scenarios.
Approach: With paired 180° pulses and based on the principle of rotary-echo to reduce artifacts, we applied numerical simulation and experiments to validate our proposed module and compare it with three existing preparation modules.
Results: Among the four modules, quadruple-refocusing shows the highest performance in compensating for artificially induced B0 and B1 field inhomogeneities.
Impact: With quadruple-refocusing, high amplitude spin-locking can be improved in the compensation of field inhomogeneities. The presented method has potential application in the T1ρ quantification in low-field MRI.
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