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Abstract #3349

Quadruple-refocused spin-locking: a robust method for high amplitude T1ρ imaging

Cai Wan1,2, Maximilian Gram3,4, Wei He1, Zheng Xu1, Qingping Chen2, Sebastian Littin2, Thomas Lange2, and Maxim Zaitsev2
1School of Electrical Engineering, Chongqing University, Chongqing, China, 2Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 3Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, 4Experimental Physics 5, University of Würzburg, Würzburg, Germany

Synopsis

Keywords: New Signal Preparation Schemes, Artifacts, T1ρ relaxation, artifact compensation, quantitative imaging

Motivation: Trelaxation mechanism during spin-locking is widely used for monitoring macromolecular remodeling, such as early-stage osteoarthritis. However, T measurements are sensitive to B0 and B1 magnetic field inhomogeneities.

Goal(s): To reduce artifacts in spin-locking and therefore to promote its potential for more application scenarios.

Approach: With paired 180° pulses and based on the principle of rotary-echo to reduce artifacts, we applied numerical simulation and experiments to validate our proposed module and compare it with three existing preparation modules.

Results: Among the four modules, quadruple-refocusing shows the highest performance in compensating for artificially induced B0 and B1 field inhomogeneities.

Impact: With quadruple-refocusing, high amplitude spin-locking can be improved in the compensation of field inhomogeneities. The presented method has potential application in the T quantification in low-field MRI.

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Keywords