Abstract #3369

Ultra-short-TR FlamingFIESTA enhances robustness of matrix-pencil functional lung MRI in pediatric cystic fibrosis patients on 1.5T GE systems

Rahel Heule^1,2, Grzegorz Bauman^3,4, Alexandra De Silvestro^1,2, Tim Sprenger^5,6, Orso Pusterla^3,4, Henric Ryden^6,7, Gabriele Raffler^2,8, Simon Vogt^2,8, Jakob Usemann^2,8,9, Julia Geiger^2,10, Alexander Moeller^2,8, Stefan Skare^6,7, Oliver Bieri^3,4, Christian Kellenberger^1,10, and Adam van Niekerk⁶

¹Center for MR Research, University Children's Hospital, Zurich, Switzerland, ²Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland, ³Department of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland, ⁴Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, ⁵MR Applied Science Laboratory Europe, GE Healthcare, Stockholm, Sweden, Stockholm, Sweden, ⁶Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, ⁸Department of Respiratory Medicine, University Children’s Hospital Zurich, Zurich, Switzerland, ⁹University Children‘s Hospital Basel (UKBB), Basel, Switzerland, ¹⁰Department of Diagnostic Imaging, University Children’s Hospital Zurich, Zurich, Switzerland

Synopsis

Keywords: Data Acquisition, Lung

Motivation: Fast time-resolved bSSFP acquisitions have shown promise for contrast agent-free functional lung MRI. Due to the off-resonance sensitivity of bSSFP, successful application of this technique requires a sufficiently short TR.

Goal(s): To enable access to reliable contrast agent-free functional pulmonary MRI based on matrix-pencil decomposition for pediatric patients on 1.5T GE MR scanners.

Approach: A dynamic 2D ultra-short-TR bSSFP sequence termed FlamingFIESTA is implemented and tailored for functional lung scans, which eliminates real-time overhead based on a packed-TR acquisition scheme.

Results: A 24% TR reduction could be achieved relative to the GE product sequence, yielding high-quality base images and improved functional data.

Impact: Ultra-short-TR FlamingFIESTA imaging considerably improves image quality and consequently functional outcome of matrix-pencil pulmonary MRI on 1.5T GE systems. This constitutes a crucial step to expand access to matrix-pencil MRI and provide a contrast agent-free alternative for chronically ill patients.

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