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Abstract #3371

Frequency-modulated bSSFP: A novel and time-efficient approach for multiparametric mapping

Nils Plähn1,2,3, Yasaman Safarkhanlo2,3,4, Eva Pepper1,2, Berk Açikgöz1,2,3, and Jessica Bastiaansen1,2
1Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 2Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 3Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland, 4Department of Cardiology, Inselspital, University Hospital Bern, Bern, Switzerland

Synopsis

Keywords: New Signal Preparation Schemes, Acquisition Methods

Motivation: Sampling a bSSFP profile using frequency-modulation (FM) is more time-efficient because steady-state preparation can be reduced, but the effect on multiparametric mapping is unknown.

Goal(s): To demonstrate that FM bSSFP can be used to map relaxation times and proton density.

Approach: FM and phase-cycled bSSFP data were acquired to obtain parametric maps in reference phantoms and in the human brain.

Results: T1 and T2 quantification using FM bSSFP agreed with nominal values of the reference with R2=0.99 respectively. FM bSSFP yielded T1, T2 and proton density maps in the brain agreeing with phase-cycled bSSFP while being 55 seconds faster.

Impact: Using frequency-modulated bSSFP as an alternative to phase-cycled bSSFP for biomarker quantification introduces new opportunities to accelerate the data acquisition. With steady-state preparation required only once, scan time is reduced, and transient state dead-time is minimized.

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