Keywords: New Signal Preparation Schemes, Acquisition Methods
Motivation: Sampling a bSSFP profile using frequency-modulation (FM) is more time-efficient because steady-state preparation can be reduced, but the effect on multiparametric mapping is unknown.
Goal(s): To demonstrate that FM bSSFP can be used to map relaxation times and proton density.
Approach: FM and phase-cycled bSSFP data were acquired to obtain parametric maps in reference phantoms and in the human brain.
Results: T1 and T2 quantification using FM bSSFP agreed with nominal values of the reference with R2=0.99 respectively. FM bSSFP yielded T1, T2 and proton density maps in the brain agreeing with phase-cycled bSSFP while being 55 seconds faster.
Impact: Using frequency-modulated bSSFP as an alternative to phase-cycled bSSFP for biomarker quantification introduces new opportunities to accelerate the data acquisition. With steady-state preparation required only once, scan time is reduced, and transient state dead-time is minimized.
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