Keywords: Diagnosis/Prediction, Magnetization transfer, Quantitative myelin imaging
Motivation: Quantitative myelin imaging methods are usually not included in clinical MRI scans for persons with multiple sclerosis.
Goal(s): Predict macromolecular pool-size-ratio maps from standard clinical scans.
Approach: Compare PSR map prediction results from linear model and neural network model.
Results: Most of the relationship between clinical scans plus DTI and PSR maps is captured by a simple linear model and the more complex nonlinear model offers minimal improvements.
Impact: Leveraging typical clinical scans to predict PSR maps using a simple linear model can improve diagnostic capabilities for multiple.
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