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Abstract #3417

Impact of multi-echo fMRI on the estimate of Integrated Local Correlation

Gulia Bosello1,2, Federica Tomaiuolo1,3, Giordano Ponetti2,4, Raffaella Franciotti2,4,5, Martin Gajdoš6, Michal Mikl6, Valeria Onofrj7,8, Piero Chiacchiaretta9,10, Mauro Gianni Perrucci2,4,5, Irena Rektorova6,11, and Antonio Ferretti2,4,5
1Department of Engineering and Geology (INGEO), University 'G. d'Annunzio' of Chieti-Pescara, Pescara, Italy, 2Institute for Advanced Biomedical Technologies (ITAB), University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy, 3Institute for Advanced Biomedical Technologies (ITAB), University 'G. d'Annunzio' of Chieti-Pescara, Pescara, Italy, 4Department of Neuroscience, Imaging, and Clinical Sciences (DNISC), University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy, 5UdA-TechLab, Research Center, University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy, 6Neuroscience Programme, Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, 7Department of Medical Imaging, Cliniques Universitaires Saint-Luc (UCLouvain), Brussels, Belgium, 8Faculty of Medicine, Masaryk University, Brno, Czech Republic, 9Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy, 10Advanced Computing Core, Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy, 11First Department of Neurology, St. Anne’s University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic

Synopsis

Keywords: Data Processing, fMRI (resting state), LCOR, multi-echo fMRI

Motivation: The impact of using optimally combined fMRI multi-echo (OC-ME) data versus single-echo (SE) techniques on local resting-state functional connectivity (rs-FC) metrics has not been assessed.

Goal(s): The study evaluates the effect of OC-ME versus SE on local brain coherence assessed with Integrated Local Correlation (LCOR).

Approach: Resting-state multi-echo data were combined into an optimized timeseries. After preprocessing SE and OC-ME data, LCOR was analyzed to assess differences in local brain coherence between the two approaches.

Results: OC-ME data resulted in significantly higher LCOR values compared to the SE approach in the anterior and posterior cingulate cortex and the right and left supramarginal gyrus.

Impact: The ME approach enhances local coherence in resting-state fMRI signals from gray matter, aligning with the known reduced thermal noise and optimized BOLD sensitivity of multi-echo data. This improved sensitivity could enable finer comparisons between conditions/groups, especially in clinical studies.

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