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Abstract #3426

Implications of Undersampling Strategy for GRAPPA-accelerated QSM and R2* Map Acquisition

Alexander Jaffray1, Christian Kames1, Alexander Rauscher1,2, and Christoph Birkl3
1Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, 3Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria

Synopsis

Keywords: Susceptibility/QSM, Susceptibility, R2* mapping, protocol optimization, partial sampling

Motivation: Similar scan durations are achievable with different acceleration strategies, introducing ambiguity in quantitative susceptibility mapping (QSM) acquisition protocols.

Goal(s):

  1. Characterization of the influence of acceleration strategy on QSM and R2* reconstructed from GRAPPA-accelerated multi-echo gradient echo data
  2. Identification of a QSM-specific recommended acceleration strategy

Approach: Three subjects were imaged at 3 T using multi-echo gradient-echo scans prospectively acquired with 9 parallel imaging acceleration strategies. QSM and R2* computed using MEDI and ARLO were compared against reconstructed maps from fully-sampled data.

Results: Partial Fourier acquisition reduces measurement precision compared to groundtruth at all GRAPPA factors. GRAPPA 3 does not significantly compromise precision or accuracy.

Impact: Strict utilization of acceleration strategies that do not rely on Partial Fourier acquisition can improve QSM accuracy, and remove ambiguity in protocol design.

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Abstract

Keywords