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Abstract #3428

Assessing Metabolic Dysfunction at Cerebral Microbleed Sites using Quantitative Oxygen Extraction Fraction MRI

Daniel Zlatopolsky1, Isabel Hagger2, Daniel Hsu2, Nazmi Kurt2, Junghun Cho3, and Salil Soman2
1Medical College of Georgia Augusta University/ University of Georgia Medical Partnership, Augusta, GA, United States, 2Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 3Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, United States

Synopsis

Keywords: Susceptibility/QSM, biomarkers, Oxygen Extraction Fraction, Cerebral Microbleed, QSM, QQ

Motivation: Cerebral microbleeds (CMBs) are hemosiderin deposits in the brain linked to multiple disease, including neurodegeneration. They are associated with vascular remodeling, blood-brain barrier dysfunction, and inflammatory processes, but their impact on neurologic function is not well understood.

Goal(s): To investigate metabolic activity at CMB sites, using a recent oxygen extraction fraction (OEF) MRI technique, QQ, to characterize dysfunction compared to non-CMB brain tissue.

Approach: QSM, SWI, and QQ MRI were conducted on 196 subjects. Regions of interest (ROIs) were analyzed for OEF at CMB sites versus surrounding tissue.

Results: Decreased OEF at CMB locations, correlating with higher QSM values, indicating reduced metabolic function.

Impact: CMB site decreased metabolic activity that worsens with increasing susceptibility suggests neurological functional damage occurrence, therapeutic targets focusing on restoring metabolic function, research directions into how CMBs disrupt local metabolism, and that QSM may serve as a biomarker for neurodegeneration.

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