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Abstract #3430

xvQSM: An Open-Source Artifact Mitigation Method for ex vivo Quantitative Susceptibility Mapping

Alexandra Grace Roberts1,2, Alexey Dimov2, Mert Sisman1, Angela Deng1, Carly Skudin2, Hangwei Zhuang2, Ilhami Kovanlikaya2, Pascal Spincemaille2, Thanh Nguyen2, Kelly Gillen2, and Yi Wang2
1Electrical Engineering, Cornell University, New York, NY, United States, 2Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping

Motivation: Ex vivo quantitative susceptibility mapping is motivated by artifacts in phantom or post-mortem reconstructions serving as gold standards for new methods. The nonlocal dipole deconvolution propagates artifacts and introduces error into these reconstructions, impeding the validation process.

Goal(s): The presented pipeline is an open-source tool to mitigate artifacts in susceptibility reconstruction and subsequent processing such as source separation and myelin mapping.

Approach: A numerical phantom and ex vivo brain tissues are reconstructed with the proposed method.

Results: Artifact reduction is observed and high structural similarity is observed.

Impact: The presented method mitigates ex vivo artifacts to increase confidence in validation. High structural similarity is observed from whole region of interest filtering and homogeneity regularization. This open-source pipeline improves source separation and potentially myelin mapping, and oxygen extraction fraction.

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Keywords