Abstract #3445

A Scalable Simulcast X-nuclei MRI System for Concurrent Multi-Frequency Transmit/Receive

Chunsheng Yang^1,2,3, Chuanxing Wu¹, Zhi Zhang², Nan Li⁴, Zekang Ding⁵, Lingzhi Hu⁶, Jianmin Yuan⁶, Kai Wang¹, and Xilin Sun¹

¹NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC) of Harbin Medical University, Harbin, China, ²Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China, ³Zhongyuan University of Technology, Zhengzhou, China, ⁴Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ⁵National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁶United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Parallel Transmit & Multiband, Non-Proton, Simulcast X-nuclei, Concurrent Multi-Frequency Transmit/Receive

Motivation: Current in vivo imaging equipment struggles to obtain multi-molecular information on diseases, particularly malignant tumors, hindering the study of their underlying molecular mechanisms.

Goal(s): To develop a novel simulcast X-nuclei MRI system for in vivo visualization of multi-molecular level information.

Approach: A modular multiband parallel transceiver console was designed based on PCIe bus architecture, and a four-frequency array RF coil was developed. The system’s functionality was validated through phantom and rabbit imaging.

Results: Simultaneous ¹H/¹⁹F/²³Na-MRI and ³¹P-MRSI were successfully achieved in a single scan with the simulcast X-nuclei MRI system.

Impact: Simultaneous and rapidly interleaved acquisition of signals from ¹H/¹⁹F/²³Na/³¹P were achieved with our Simulcast X-nuclei MRI system, which provides inspiring possibilities for in vivo simultaneously characterizing lesion site structure, molecular targets, ion perturbations and energy metabolism information.

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