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Abstract #3493

Magnetic Resonance Metabolomics on blood as a predictor of metastatic disease in melanoma

Nichlas Vous Christensen1, Malene Aastrup1, Esben Søvsø Szocska Hansen1, Daniel Radford-Smith2, Pippa Corrie3, Mark Middleton4, Andrea Marshall5, Christoffer Laustsen1, Fay Probert6, Daniel Anthony2, James R Larkin2, and Jack Miller1
1MR Research Centre, Aarhus Universitet, Aarhus, Denmark, 2Department of Pharmacology, University of Oxford, Oxford, United Kingdom, 3Cambridge Cancer Centre, University of Cambridge, Cambridge, United Kingdom, 4Department of Oncology, University of Oxford, Oxford, United Kingdom, 5WMS - Warwick Clinical Trials Unit, University of Warwick, Warwick, United Kingdom, 6Department of Chemistry, University of Oxford, Oxford, United Kingdom

Synopsis

Keywords: Diagnosis/Prediction, Cancer, Spectroscopy; NMR; Prediction; Metabolomics

Motivation: Malignant melanoma is an aggressive skin cancer, typically associated with a poor prognosis due to distant, invasive metastasis that are often challenging to diagnose.

Goal(s): We wished to see if a previously-applied whole-blood MR metabolomics classification algorithm could distinguish patients with distant metastasis from those with only locally advanced disease

Approach: We have recently received consent to undertake this trial on 200 melanoma patients who may have undiagnosed distant metastasis at the time of sampling. We undertook 600MHz CPMG spectroscopy on whole blood and will subsequently perform cross-validated OPLS-DA on 0.01ppm spectral buckets in an attempt to build a clinically-useful classifier.

Impact: Patients with resected AJCC stage IIB/C and III cutaneous melanoma are at high risk of recurrent disease with poor prognosis. An inexpensive blood biopsy able to predict those with distant metastatic disease would guide clinical decision making and save lives.

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