Keywords: Alzheimer's Disease, Quantitative Imaging
Motivation: Evidence has been proven that pathological changes in myelin may precede the classic pathological changes of Alzheimer’s disease (AD).
Goal(s): Assess the feasibility of Synthetic MRI (SyMRI) in detecting myelopathology in early AD diagnosis. Reveal the relationship between myelin sheath and clinical manifestations.
Approach: Brain MRI scans are performed on 30 AD patients and 25 controls. SyMRI-derived relaxometry and myelin maps, along with neurofunctional and structural metrics from BOLD and NODDI, are analyzed.
Impact: This study could improve early Alzheimer’s diagnosis by combining SyMRI, myelin mapping, BOLD, and NODDI to identify early biomarkers of the disease.
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