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Abstract #3498

Utilizing synthetic MRI and brain functional analysis for early Alzheimer’s disease diagnosis

Ke Dong1, Jie Shi2, Yao Xiao1, Lefan Yu1, Yi Shang1, and Hui Dai1
1Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow, China, 2MR Research, GE HealthCare, Shanghai, China

Synopsis

Keywords: Alzheimer's Disease, Quantitative Imaging

Motivation: Evidence has been proven that pathological changes in myelin may precede the classic pathological changes of Alzheimer’s disease (AD).

Goal(s): Assess the feasibility of Synthetic MRI (SyMRI) in detecting myelopathology in early AD diagnosis. Reveal the relationship between myelin sheath and clinical manifestations.

Approach: Brain MRI scans are performed on 30 AD patients and 25 controls. SyMRI-derived relaxometry and myelin maps, along with neurofunctional and structural metrics from BOLD and NODDI, are analyzed.

Impact: This study could improve early Alzheimer’s diagnosis by combining SyMRI, myelin mapping, BOLD, and NODDI to identify early biomarkers of the disease.

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