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Abstract #3526

Meal-induced changes of proton density fat fraction and T2* in supraclavicular adipose tissue

Johannes Raspe1, Tianxing Du2, Jonathan Stelter1, Mingming Wu1, Martin Klingenspor2,3,4, Thomas Skurk2, and Dimitrios C. Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, 2ZIEL - Institute for Food & Health, School of Life Sciences, Technical University of Munich, Freising, Germany, 3Chair of Molecular Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany, 4Else-Kröner-Fresenius Center for Nutritional Medicine, School of Life Siences, Technical University of Munich, Munich, Germany

Synopsis

Keywords: Fat & Fat/Water Separation, Fat and Fat/Water Separation, Metabolism

Motivation: Investigating brown adipose tissue (BAT) non-invasively has attracted attention as BAT may serve as a target for treating metabolic diseases.

Goal(s): To investigate meal-induced changes in activated human BAT.

Approach: Ten volunteers received isocaloric meals after fasting (activation experiment). MRI was performed at baseline and one hour post-meal using 12-echo radial stack-of-stars Dixon scans to assess proton density fat fraction (PDFF) and T2*changes. MRI was also performed after fasting without meals (control experiment) at baseline and one hour post-fasting.

Results: PDFF and T2* decreased significantly in the activation experiment compared to control. Both parameters showed a simultaneously decreasing trend in the same voxels.

Impact: Human brown adipose tissue (BAT) is metabolically activated by meal consumption. Comparing proton density fat fraction (PDFF) and T2* changes between activation and control experiments, this study is the first to give insights into postprandial responses of BAT using MRI.

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