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Abstract #3530

Single-shot distortion-corrected water-fat separation using multi-echo blip-rewound EPI for diffusion-weighted imaging

Yiming Dong1, Peter Börnert1,2, Ziyu Li3, Xinyu Ye3, Matthias J.P. van Osch1, Karla Miller3, and Wenchuan Wu3
1C.J. Gorter MRI Center, Department of Radiology, LUMC, Leiden, Netherlands, 2Philips Innovative Technologies Hamburg, Hamburg, Germany, 3Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Synopsis

Keywords: Diffusion Acquisition, Diffusion Reconstruction

Motivation: Single-shot EPI(ss-EPI) is widely used in diffusion-weighted imaging(DWI) but suffers from geometric distortion and failure of fat suppression especially in inhomogeneous B0/B1 regions. Dixon-based water-fat separation allows robust fat suppression but is prone to echo-to-echo phase variation in DWI.

Goal(s): Develop a single-shot water-fat separation to achieve motion-robust fat suppression and distortion correction for DWI.

Approach: We integrated multi-echo blip-rewound EPI(rEPI) with chemical-shift encoding to acquire three TE-shifted DWI images in a single readout, followed by water-fat separation and distortion correction.

Results: Effective fat suppression and distortion correction were achieved in phantom and in-vivo scans, producing high-quality DWI images across multiple anatomies.

Impact: This method provides a time-efficient, motion-robust approach for water-fat separation and distortion correction in DWI, improving diagnostic reliability in complex anatomical regions. Its single-shot acquisition design holds promise for expanding DWI applications in both routine clinical and challenging environments.

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