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Abstract #3549

Cerebral Blood Flow Assessment in Bronchopulmonary Dysplasia With or Without Neonatal Pneumonia in Preterm Infants

Ning Wang1, Lin Lu1, Kaiyu Wang2, Lingsong Meng3, Junjie Liao1, and Xinqi Li1
1Department of Radiology, the Third Affiliated Hospital of Zhengzhou University, ZhengZhou, China, 2MR Research China, GE Healthcare, Beijing, China, 3Shangqiu Medical College, Department of Medical Technology, Shangqiu, China

Synopsis

Keywords: fMRI Analysis, Arterial spin labelling, cerebral blood flow; bronchopulmonary dysplasia; neonatal pneumonia; preterm

Motivation: Infants with bronchopulmonary dysplasia (BPD) are prone to lung infections, such as pneumonia, due to structural and functional abnormalities. Recurrent pneumonia can exacerbate lung inflammation and worsen BPD.

Goal(s): This study investigates the value of 3D-ASL in assessing cerebral hemodynamics in preterm infants with BPD, with or without neonatal pneumonia (NP).

Approach: We compared cerebral blood flow (CBF) values across different brain regions among BPD-NP, BPD, and control groups, evaluating CBF's predictive ability for disease diagnosis and long-term neurodevelopmental outcomes.

Results: Infants with BPD showed increased CBF, negatively correlating with CDCC scores, with combined CBF values demonstrating optimal diagnostic performance.

Impact: This study examined changes in cerebral blood flow in preterm infants with or without neonatal pneumonia using 3D-ASL. The findings may enhance clinical management and care for vulnerable populations affected by lung and brain diseases.

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Keywords