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Abstract #3555

Holistic brain functional parcellation in young children

Kimhan Thung1,2, Wenjiao Lyu1,2, Khoi Minh Huynh1,2, Sahar Ahmad1,2, and Pew-Thian Yap1,2
1Department of Radiology, UNC at Chapel Hill, Chapel Hill, NC, United States, 2Biomedical Research Imaging Center, UNC at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, Early brain development; functional networks; functional parcellation

Motivation: Early brain function differs significantly from adults, but the lack of a dedicated children’s parcellation atlas makes studying brain developmental patterns challenging.


Goal(s): To create a child-specific whole-brain functional parcellation that enables comprehensive analysis of functional networks across the brain.


Approach: We preprocess the (0-5years) children’s resting-state fMRI data, and employ group independent component analysis, probabilistic threshold-free cluster enhancement, and a winner-takes-all strategy to functionally parcellate the brain.

Results: Our early life functional parcellation closely resembles adult parcellations in primary function networks and the default mode network, with some differences observed in other higher-order networks.

Impact: We present a comprehensive whole-brain functional parcellation for infants and young children, offering a detailed view of early brain function. This parcellation supports studies on brain development and advances research on disorders affecting infants and young children.

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Keywords