Meeting Banner
Abstract #3557

Altered Functional Brain Activity and Connectivity in Children with β-Thalassemia: A Resting-State fMRI Study

Haifeng Zheng1, Muliang Jiang1, Yifeng Wang2, Hang Yu2, Wei Cui3, Jiali Liang1, Haoling He1, Xingye Yang1, Rong Wang1, Meiru Bu4, and Xi Deng1
1The First Affiliated Hospital of Guangxi Medical University, Nanning,Guangxi Province, China, 2Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu,Sichuan Province, China, 3GE Healthcare, MR Research China, Nanning,Guangxi Province, China, 4Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning,Guangxi Province, China

Synopsis

Keywords: Functional Connectivity, fMRI Analysis, cognitive impairment

Motivation: Cognitive and functional impairments are common in β-Thalassemia (β-TM) patients, but functional brain alterations, particularly in children, are not well understood.

Goal(s): Investigate functional brain activity and connectivity in children with β-TM using resting-state fMRI.

Approach: Resting-state fMRI data were acquired from 49 β-TM children with cognitive impairments and 45 healthy controls to compare functional activity and ALFF between the groups.

Results: β-TM patients showed reduced ALFF in the right frontal pole, precuneus, and left precentral gyrus. Increased connectivity was observed between the right posterior parietal cortex and anterior cerebellum, with decreased connectivity between the anterior cerebellum and left lateral visual cortex.

Impact: This study reveals dysfunction in several brain regions in children with β-TM, particularly in the frontal pole, precuneus, and visual cortex. These findings may enhance understanding of cognitive impairment mechanisms and support the development of targeted interventions for β-TM.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords