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Abstract #3560

Periventricular White Matter Hyperintensity Prunes the Resting State Connectivity of Default Mode Network with Aging

Vivek Tiwari1, Niraj K Gupta1, Ananya Praharaj1, and Neha Yadav1
1Indian Institute of Science Education and Research Berhampur, Berhampur, India

Synopsis

Keywords: Functional Connectivity, Aging

Motivation: Default-Mode-Network (DMN) connectivity, central for memory, attention, and executive-functions, may get disrupted with accumulation of Cerebral-small vessel-disease load as Periventricular and deep-white-matter-hyperintensity (PVWMH-and-DWMH) volume beyond a threshold, impacting cognition.

Goal(s): To quantify whether PVWMH/DWMH alters DMN functional connectivity, accelerating cognitive decline compared to age-matched healthy individuals without WMH.

Approach: Seed-based network-analysis of DMN-regions (PCC, mPFC, LP) was conducted with aging in ADNI cohort of normal aging subjects, alongside PVWMH/DWMH segmentation and quantification.

Results: DMN remains intact in subjects without PVWMH; however, PVWMH >5 ml at age >75 years disrupts DMN, suggesting WMH mediates cognitive-impairments via impaired resting-state networks with progression in age.

Impact: This study reveals a threshold of periventricular white matter hyperintensity impacting default mode network connectivity with age, highlighting WMH load’s role in disrupting connectivity. Resting-state network health and WMH load are essential for understanding cognitive aging trajectories.

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