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Abstract #3563

Changes of cortical functional complexity across the lifespan in men and women

Dilmini Wijesinghe1, Kirsten Lynch1, Leon Aksman1, Danny JJ Wang1, and Kay Jann1
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine at University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), Complexity, Multiscale Sample Entropy

Motivation: To investigate lifespan trajectories of integrity of regional brain function by means of fMRI-complexity.

Goal(s): The goal of this study is to analyze changes of fMRI-complexity over the lifespan among men and women using Multiscale Sample Entropy.

Approach: Complexity trajectories of 504 subjects age ranging from 6 – 85 years were analyzed using polynomial model fitting and Bayesian Information Criterion.

Results: Majority of cortical brain regions showed a complexity peak between age 22 and 24yrs. There is a complexity maturation delay in men compared to women however after reaching the peak complexity, the women exhibited a slightly faster decline in complexity than men.

Impact: The findings of this study help to understand the lifespan trajectories of the complexity of regional brain function among men and women.

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Keywords