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Abstract #3566

The Functional Connectivity Changes of Default-Mode Network in Monkeys after Acute Stress Exposure

Chun-Xia Li1, Xiaodong Zhang1, Michael T. Treadway2,3, and Vasiliki Michopoulos4
1EPC Imaging Center, Emory National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Psychology, Emory University, Atlanta, GA, United States, 3Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States, 4Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, Atlanta, GA, United States

Synopsis

Keywords: Functional Connectivity, biology, models, methods

Motivation: How stress results in alterations to the resting-state functional connectivity (FC) profiles is not fully addressed.

Goal(s): This study was to investigate whether stress-induced alterations in the default mode network (DMN), as observed in humans, could be replicated in adult female monkeys.

Approach: The resting state functional MRI (rsfMRI) data of 18 female monkeys before and after acute stress (relocation and social isolation) were acquired and analyzed.

Results: Significantly increased FC between the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) following acute stress were seen.

Impact: Monkeys could replicate the FC alteration in humans after stress and provide a unique platform for preclinical stress-related disorders.

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Keywords