Abstract #3569

Characterizing hemodynamic responses across species in the awake state

Qian Chen¹, Cecil Chern-Chyi Yen², Alan P. Koretsky², Afonso C. Silva³, Zhifeng Liang⁴, and Zhiwei Ma^1,5,6

¹School of Biomedical Engineering, ShanghaiTech Unversity, Shanghai, China, ²National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ³Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China, ⁵State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China, ⁶Shanghai Clinical Research and Trial Center, Shanghai, China

Synopsis

Keywords: fMRI Analysis, fMRI (task based), hemodynamic response function, awake animals, translational neuroimaging

Motivation: Although physiological differences are more pronounced during wakefulness, interspecies similarities or differences in cerebral hemodynamic responses in the awake state have not been elucidated.

Goal(s): To identify interspecies similarities or differences by analyzing hemodynamic response functions (HRFs) of awake mice, marmosets, and humans.

Approach: The fMRI datasets of the three species were analyzed using the general linear model. Temporal characteristics of the HRFs (onset, time to peak [TTP], full-width at half maximum [FWHM]) were calculated and statistically compared across species.

Results: While HRF shapes were similar across species, differences in TTP and FWHM were found, indicating species-specific temporal characteristics of hemodynamic responses.

Impact: Our findings reveal species-specific hemodynamic differences in the awake state, enhancing translational research between awake animal models and human neuroimaging.

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