Keywords: Task/Intervention Based fMRI, fMRI (task based), animals, somatosensory stimulation, frequency
Motivation: Different anesthesia methods have different physiological effects on the cortex and subcortex, resulting in inconsistent activation strength during fMRI.
Goal(s): To investigate the frequency-dependent fMRI activation of somatosensory pathways evoked by electrical stimulation of the rat forelimb under dextrotomidine sedation.
Approach: We conducted fMRI on 9 rats using an 11.7T animal scanner with EPI, applying classical forelimb stimulation under dexmedetomidine anesthesia.
Results: We observed brain-wide activation in response to forelimb stimulation, with distinct patterns across regions. Notably, frequency-dependent BOLD responses were most significant at 4 and 8 Hz in S1 and S2, while elevated FWHM also detected in VPL, Po, SC, and SV.
Impact: Bilateral forelimb stimulation activated S1FL, S2, VPL, and Po under dexmedetomidine anesthesia. High-frequency stimulation also induced strong onset activation in these regions, while no offset activation. This suggests dexmedetomidine is a promising anesthetic reflecting the physiological state like awake animals.
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