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Abstract #3576

Frequency-dependent BOLD fMRI to somatosensory stimuli in dexmedetomidine-anesthetized rats

Zijuan Yu1,2, Haoyu Wang3, Yan Zhuo1,2, and Zhentao Zuo1,2
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, CAS, Beijing, China, 2University of Chinese Academy of Sciences, CAS, Beijing, China, 3Beijing Institute of Radiation Medicine, Beijing, China

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based), animals, somatosensory stimulation, frequency

Motivation: Different anesthesia methods have different physiological effects on the cortex and subcortex, resulting in inconsistent activation strength during fMRI.

Goal(s): To investigate the frequency-dependent fMRI activation of somatosensory pathways evoked by electrical stimulation of the rat forelimb under dextrotomidine sedation.

Approach: We conducted fMRI on 9 rats using an 11.7T animal scanner with EPI, applying classical forelimb stimulation under dexmedetomidine anesthesia.

Results: We observed brain-wide activation in response to forelimb stimulation, with distinct patterns across regions. Notably, frequency-dependent BOLD responses were most significant at 4 and 8 Hz in S1 and S2, while elevated FWHM also detected in VPL, Po, SC, and SV.

Impact: Bilateral forelimb stimulation activated S1FL, S2, VPL, and Po under dexmedetomidine anesthesia. High-frequency stimulation also induced strong onset activation in these regions, while no offset activation. This suggests dexmedetomidine is a promising anesthetic reflecting the physiological state like awake animals.

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Keywords