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Abstract #3584

Retrospective Analysis of Diffusion Tensor Imaging from the SPRINT-MS Clinical Trial: Advancing Trial Methodology

Ken Sakaie1, Mengke Du2, Mark J. Lowe1, Jian Lin1, and Robert J. Fox3
1Diagnostic Radiology, The Cleveland Clinic, Cleveland, OH, United States, 2Quantitative Health Sciences, The Cleveland Clinic, Cleveland, OH, United States, 3Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: There are few treatment options for progressive multiple sclerosis (MS). Imaging biomarkers play an important role in clinical trials of treatment for relapsing-remitting MS, but imaging biomarkers with demonstrated usefulness in progressive MS are lacking.

Goal(s): To identify potential imaging biomarkers for use in clinical trials of therapies for the progressive multiple sclerosis (MS).

Approach: A retrospective analysis of diffusion tensor imaging (DTI) data from SPRINT-MS, a placebo-controlled phase 2 trial of Ibudilast for progressive MS was performed.

Results: Radial diffusivity in cingulum and superior cerebellar peduncles was significantly different between treatment and placebo groups (p < 0.04).

Impact: The cingulum and cerebellar peduncle are potential areas for focus in the evaluation of therapies in progressive MS.

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