Keywords: Multiple Sclerosis, Multiple Sclerosis
Motivation: There are few treatment options for progressive multiple sclerosis (MS). Imaging biomarkers play an important role in clinical trials of treatment for relapsing-remitting MS, but imaging biomarkers with demonstrated usefulness in progressive MS are lacking.
Goal(s): To identify potential imaging biomarkers for use in clinical trials of therapies for the progressive multiple sclerosis (MS).
Approach: A retrospective analysis of diffusion tensor imaging (DTI) data from SPRINT-MS, a placebo-controlled phase 2 trial of Ibudilast for progressive MS was performed.
Results: Radial diffusivity in cingulum and superior cerebellar peduncles was significantly different between treatment and placebo groups (p < 0.04).
Impact: The cingulum and cerebellar peduncle are potential areas for focus in the evaluation of therapies in progressive MS.
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