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Abstract #3587

Synthesis of Double Inversion Recovery-like Images for Superior Contrast and Multiple Sclerosis Lesion Visibility

Long Wang1, Campbell Arnold1, Zechen Zhou1, Lei Xiang1, Ajit Shankaranarayanan1, Suzie Bash2, and Lawrence Tanenbaum3
1Subtle Medical, Menlo Park, CA, United States, 2RadNet, Los Angeles, CA, United States, 3drt consulting, Riverside, CT, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, Double Inversion Recovery

Motivation: Double Inversion Recovery (DIR) can enhance lesion detection, particularly in multiple sclerosis (MS) where juxtacortical and infratentorialplaques are challenging to detect with conventional techniques.

Goal(s): This study evaluates DIR-like images(Syn-DIR) generated from T1 and T2 FLAIR for brain structure and lesion visibility

Approach: The study evaluates 30 subjects to assess quantitative segmentation, volumetric consistency, and lesion-to-white-matter contrast. A second longitudinal study cohort assessed 20 additional subjects scanned at two time points to evaluate performance consistency over time.

Results: Syn-DIR demonstrated high structural agreement to the reference set and showed significantly higher lesion-to-white matter contrast, with stable gray-to-white-matter contrast across time points.

Impact: Syn-DIR provides superior lesion visibility and consistent brain structure representation. The strong agreement in quantitative lesion and regional brain volumes demonstrates its robustness for clinical and research applications.

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