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Abstract #3589

Assessment of multiple sclerosis using divided subtracted inversion recovery (dSIR) technique: a quantitative study

Jing Huang1, Jiyuan Wang1, Yi Shan1, Cheng Zhao1, Boyan Xu2, Yajun Ma3, and Jie Lu1
1Xuanwu hospital, Beijing, China, 2GE Healthcare, MR Research China, Beijing, Beijing, China, 3Department of Radiology, University of California San Diego, San Diego, CA, USA, San Diego, CA, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, magnetic resonance imaging, divided subtracted inversion recovery

Motivation: The dSIR technique provides ultra-high image contrast; However, its usefulness for MS patients needs further study.

Goal(s): This study aimed to evaluate dSIR measurements of deep gray matter (GM) nuclei and white matter (WM) lesions in MS patients and analyze their correlation with clinical assessments.

Approach: Quantitative values for GM nuclei and WM lesions were measured from their dSIR images.

Results: MS patients showed higher dSIR values in GM nuclei than healthy controls (HCs), enabling distinguishing patients from HCs with an area under the curve of about 0.81-0.92. The dSIR values of WM lesions moderately correlated with patients' cognitive and physical disability scores.

Impact: The dSIR sequence can effectively quantitatively evaluate the abnormal changes of deep GM nuclei and WM lesions in MS patients and may be used for clinical monitoring of patients' cognitive and disability status.

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Keywords