Abstract #3592

QSM Source Separation Detects Treatment Effect of Ocrelizumab on Multiple Sclerosis Lesion Myelin: A Longitudinal Study

Mert Sisman^1,2, Kimberly Markowitz³, Ha M. Luu², Hannah Schwartz³, Iliana Pliska-Bloch³, Pascal Spincemaille², Ilhami Kovanlikaya², Sandra M. Hurtado Rua⁴, Susan A. Gauthier³, Yi Wang^2,5, and Thanh D. Nguyen²

¹Electrical and Computer Engineering, Cornell University, New York, NY, United States, ²Department of Radiology, Weill Cornell Medicine, New York, NY, United States, ³Department of Neurology, Weill Cornell Medicine, New York, NY, United States, ⁴Department of Mathematics and Statistics, Cleveland State University, Cleveland, OH, United States, ⁵Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, Myelin, iron

Motivation: Noninvasive tools for monitoring the changes in tissue during treatment is an important clinical need. In Multiple Sclerosis (MS), estimation of iron and myelin content is essential.

Goal(s): This study aims to demonstrate the potential of a newly developed technique for myelin and iron change detection during treatment from gradient-echo data.

Approach: Data from 29 MS patient were retrospectively collected over a period of time that covers the treatment start and all data were processed to estimate iron and myelin biomarkers.

Results: Statistical analyses showed that the Ocrelizumab treatment caused overall iron decrease and remyelination.

Impact: Treatment efforts in Multiple Sclerosis includes medications that suppress acute inflammation. Therefore, the noninvasive quantification of the effect of treatment on the iron change and remyelination carries significant importance. Here, a novel gradient-echo based approach is tested for this purpose.

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