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Abstract #3596

fMRI Examination of the Spatiotemporal Alterations of Brain Networks in Rodent Model of Acute Neuroinflammation

Qiuyi Lyu1,2,3, Junjian Wen2,3, Linshan Xie2,3, Teng Ma2,3,4, Peng Cao4, Ed X. Wu2,3,5, Alex T. L Leong2,3, and Zhangjin Zhang1
1School of Chinese Medicine, The University of Hong Kong, Hong Kong SAR, China, 2Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 3Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 4Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 5School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Synopsis

Keywords: Neuroinflammation, fMRI (resting state), neuroinflammation, functional connectivity, neuroscience

Motivation: Neuroinflammation plays a critical role in various neurological and psychiatric disorders, yet its large-scale functional impacts remain poorly understood.

Goal(s): This study aims to establish an acute neuroinflammation rat model and investigate the associated behavioral changes and brain network alterations.

Approach: We utilized resting-state fMRI to characterize the neuroinflammation-induced brain functional abnormalities and explore whether these changes contribute to the emergence of depressive-like behaviors.

Results: This study revealed that acute neuroinflammation in rats leads to spatiotemporal alterations in brain functional networks, characterized by a shift from integrated cortical-subcortical interactions to a segregated state, potentially mediated by the retrosplenial cortex.

Impact: This study examines the brain-wide functional alterations in acute neuroinflammation rat models. The observed changes in retrosplenial cortex-related brain networks provide new insights into the mechanisms of neuroinflammation-induced depressive symptoms and potential therapeutic targets.

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Keywords