Keywords: Neuroinflammation, Quantitative Susceptibility mapping
Motivation: The neuroprotective effects of Epigallocatechin-3-gallate (EGCG) on chronic high altitude (HA)-induced nerve damage have not been reported.
Goal(s): The purpose of this study is to use quantitative susceptibility mapping (QSM) to dynamically evaluate the status of brain damage and the effect of EGCG at HA.
Approach: A model of HA environments-induced brain injury was established for different weeks. Neural ultrastructural changes were evaluated with electron microscope. Salidroside treatment was chosen as the positive control group.
Results: The susceptibility values in the hippocampus, ferritin, iron content increased significantly after HA exposure. EGCG attenuated HA environments-induced cognitive impairment, iron accumulation, microglial activation and neural degeneration.
Impact: The effects of EGCG in reducing EPO and metal chelating property about iron were dose-dependent, with effects of EGCG being similar to those of salidroside.
QSM provides a potential complementary imaging technique to detect the effect of treating HA diseases.
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