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Abstract #3603

Molecular imaging of radiotherapy-induced cerebrovascular inflammation and neuroinflammation in a rat model of stereotactic radiosurgery.

Evgeniia Molokova1, Réjean Lebel1, Flavie Raccah1, Adam Bourissai1, Dina Sikpa1, Prenitha Ignatius1, Gabriel Richard2, Luc Tremblay1, Serge Phoenix2, Brigitte Guérin1, and Martin Lepage1
1Université de Sherbrooke, Sherbrooke, QC, Canada, 2Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada

Synopsis

Keywords: Neuroinflammation, Radiotherapy, Cerebrovascular inflammation, VCAM-1, MPIOs, BBB permeability, DCE-MRI, PET, TSPO, molecular imaging, stereotactic radiosurgery, biomarkers

Motivation: Despite the advances in radiotherapy of brain tumors adverse radiation effects in healthy brain tissue can occur. Their underlying mechanisms are not fully understood, though previous research proposes the contribution of cerebrovascular impairment and neuroinflammation.

Goal(s): Evaluate the development of BBB impairment, cerebrovascular inflammation and neuroinflammation in the rat model of stereotactic radiosurgery.

Approach: Multi-modality molecular imaging including DCE-MRI, T2*-weighted MRI with VCAM-1 MPIOs and PET with TSPO-specific radiotracer.

Results: In the rat model of SRS increased BBB permeability, cerebrovascular inflammation and neuroinflammation can be detected as early as 6 weeks after irradiation and these changes evolve over time in dose-dependent manner.

Impact: It is the first study to demonstrate by in vivo imaging the progression of neuroinflammatory and cerebrovascular alterations in the rat model of SRS which helps to understand the time and dose-dependent manner of development of adverse radiation effects.

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Keywords