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Abstract #3623

Improved T2* mapping in fetal brain and placenta using fast multiple overlapping-echo acquisition

Qinqin Yang1, Nuowei Ge1, Jianfeng Bao2, Shuhui Cai1, Zhong Chen1, and Congbo Cai1
1Department of Electronic Science, Xiamen University, Xiamen, China, 2Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: Fetal, Fetal

Motivation: T2* mapping provides valuable information on blood oxygenation and function in the fetal brain and placenta. However, the widely used multi-echo EPI method suffers from low spatial resolution and geometric distortion.

Goal(s): To improve the spatial resolution and reduce distortion of fetal or placental T2* mapping.

Approach: The gradient-echo-based multi-overlapping-echo acquisition (GRE-MOLED) was developed in fetal and placental MRI, and was validated on agar-based phantom and six pregnant women.

Results: Phantom experiments demonstrated the distortion correction capability and accurate T2* mapping performance of GRE-MOLED. Preliminary fetal and placental T2* maps showed reasonable T2* values and improved spatial resolution.

Impact: The proposed GRE-MOLED method achieves improved T2* mapping for the fetal brain and placenta within the same acquisition time as conventional EPI method, offering a promising solution to the limitations of low spatial resolution and distortion artifacts.

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