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Abstract #3626

Direct Measurement of Fetus Water Dynamics Using 17O-MRI

Nobuhiro Nitta1,2, Hong Zhang3, Moyoko Tomiyasu2, Yasuhiko Tachibana2, Jeff Kershaw2, Kohsuke Kudo4, and Takayuki Obata2
1Bio Imaging Center, Central Institute for Experimental Medicine and Life Science (CIEM), Kawasaki, Japan, 2Applied MRI Research, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science (QST), Chiba, Japan, 3Advanced Neuroimaging Center, Institute for Quantum Medical Science (QST), Chiba, Japan, 4Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Hokkaido, Japan

Synopsis

Keywords: Small Animals, Non-Proton, Oxigen-17

Motivation: Water circulation disorders during pregnancy may affect both fetus and maternal health. Unfortunately, the underlying mechanisms are largely unknown, in part because there is no imaging technique that can non-invasively visualize the water dynamics.

Goal(s): Establish a non-invasive method to directly observe fetus water dynamics using Oxygen-17 MRI.

Approach: Pregnant mice were administered 17O-labeled water and 17O-MRI was conducted to evaluate whether fetus water dynamics could be directly visualized.

Results: Fetal water dynamics was successfully observed with 17O-MRI.

Impact: This is the first report of a direct, non-invasive method that has successfully observed fetus water dynamics.

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Abstract

Keywords