Abstract #3630
Stability and Measurement Variability of a Cardiac T1 and T2 Relaxometry Phantom
Carly Anne Lockard1, Ruei-yuan Tu1, Ke Yan2, Aspen Duffin3,4, Kimberly Crum5, Scott Auerbach6, Brian Fonseca6, Markus Renno7, Kenneth Knecht7, Tiffanie Johnson8, Nicholas Brown9, Erin Albers9, Nazia Husain10, Rebecca Beroukhim11, Kevin Daly11, Margaret M Samyn3,4, Jonathan H Soslow5, and Bruce M Damon1,12,13,14,15,16
1Stephens Family Clinical Research Institute, Carle Clinical Imaging Research Program, Carle Health, Urbana, IL, United States, 2Quantitative Health Sciences, Medical College of Wisconsin, Milwaukee, WI, United States, 3Medical College of Wisconsin, Milwaukee, WI, United States, 4Herma Heart Institute, Children’s Wisconsin, Milwaukee, WI, United States, 5Vanderbilt University Medical Center, Nashville, TN, United States, 6Children’s Hospital Colorado, Denver, CO, United States, 7Arkansas Children’s Hospital, Little Rock, AR, United States, 8Riley Hospital for Children at Indiana University Health, Indianapolis, IN, United States, 9Seattle Children’s Hospital, Seattle, WA, United States, 10Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, United States, 11Boston Children’s Hospital, Boston, MA, United States, 12Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 13Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 14Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 15Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 16Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States
Synopsis
Keywords: Phantoms, Phantoms, Cardiovascular
Motivation: Cardiac magnetic resonance (CMR) parametric mapping is the gold standard for assessment of myocarditis and critical for multiple other types of acquired and congenital heart disease. Measurement drift over time can introduce bias, and parametric mapping guidelines suggest monitoring drift with a phantom; commercial phantoms are costly and have limited availability.
Goal(s): To measure custom-built phantom multi-site temporal stability and measurement variation.
Approach: We investigated the stability and measurement variation of manganese-chloride solution cardiac phantom T2 and T1 at multiple sites with different scanners/field-strengths.
Results: We observed excellent stability for physiologically relevant phantom T2 and T1 measurements at sites for 15 months.
Impact: Our preliminary results show that the designed phantom appears stable up to 15 months and allows quantification of measurement variation at different sites.
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