Keywords: Phantoms, Phantoms
Motivation: A physiologic phosphorus phantom system is needed to validate/test phosphorus MR technology.
Goal(s): The goal of this study was to adapt a phosphorus buffer solution to serve as a tunable phantom system.
Approach: Sodium hydroxide was added to phosphoric acid in different amounts to generate singlets at different resonant frequencies.
Results: Phosphoric acid singlets could span a 5 ppm range. Singlets could be positioned at spectral position. However, singlets had different areas with different [NaOH], probably due to different T1 times.
Impact: The cellular metabolic energetic metabolites ATP and PCr are known to differ in disease and health. Measuring these compounds in humans has proven difficult. Better phosphorus MRS/MRI technology is needed, as well as the tools to test/validate this technology.
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