Keywords: Small Animals, fMRI Acquisition
Motivation: We want to push the limit of spatial resolution to gain robust BOLD fMRI with an ultra-high field scanner.
Goal(s): The objective is to develop an ultra-high resolution functional mapping method to specify the vessel-specific hemodynamic and vasodynamic responses with fMRI.
Approach: We implanted a Figure-8 RF coil above the mouse skull to boost SNR and implemented high-resolution multi-slice EPI to measure the evoked BOLD signals.
Results: We identified the sparsed BOLD signals spreading through the cortical vasculature. These high-resolution results allowed us to identify the smoothing effect to diminish the vessel-specificity of BOLD-fMRI.
Impact: To resolve the vessel-specificity of fMRI with ultra-high resolution method at the brain-wide scale would open a new avenue to study hemodynamic and vasodynamic responses given its direct vascular origin.
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