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Abstract #3652

Cerebral change of the fractional amplitude of low frequency fluctuation (fALFF) in a harmaline-induced tremor rat model

Sheng-Min Huang1, Kuan-Hung Cho2, and Li-Wei Kuo3,4
1Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Department of Electronic Engineering, National United University, Miaoli, Taiwan, 3Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 4Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

Synopsis

Keywords: Small Animals, fMRI (resting state), tremor rat

Motivation: While the harmaline-induced tremor rat model is based on cerebellar circuitry, its impact on the cerebrum remains unknown.

Goal(s): Assess the cerebral activity in harmaline-induced rat tremor model.

Approach: Resting-state fMRI scan of the harmaline-administered SD rat.

Results: Comparing to control, increased fALFF in prefrontal area, cingulate cortex, restrosplenial cortex, and motor area was found in the harmaline-induced tremor rat. Such results indicate that, in addition to the tremor cerebellar circuit and motor function, harmaline can also alter the resting-state activity in other key brain regions.

Impact: This study shows the fALFF changes in the cerebrum of the harmaline-induced tremor rat model, providing the first insight into the brain activity of cerebral area in addition to classical tremor cerebellar circuit.

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Keywords