Keywords: Small Animals, fMRI (resting state), tremor rat
Motivation: While the harmaline-induced tremor rat model is based on cerebellar circuitry, its impact on the cerebrum remains unknown.
Goal(s): Assess the cerebral activity in harmaline-induced rat tremor model.
Approach: Resting-state fMRI scan of the harmaline-administered SD rat.
Results: Comparing to control, increased fALFF in prefrontal area, cingulate cortex, restrosplenial cortex, and motor area was found in the harmaline-induced tremor rat. Such results indicate that, in addition to the tremor cerebellar circuit and motor function, harmaline can also alter the resting-state activity in other key brain regions.
Impact: This study shows the fALFF changes in the cerebrum of the harmaline-induced tremor rat model, providing the first insight into the brain activity of cerebral area in addition to classical tremor cerebellar circuit.
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