Abstract #3677

Ventriculo-Arterial Coupling estimation by Cardiac MRI as a potential biomarker in patients with repaired Tetralogy of Fallot

Tyler Shimfessel¹, Maria Gusseva¹, Animesh A Tandon², Ann Marie Valente³, Tal Geva³, Anais Marenco³, Philipp Beerbaum⁴, Thomas Pickardt⁵, Samir Sarikouch⁶, Radomir Chabiniok¹, Gerald Greil¹, and Tarique Hussain¹

¹University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Cleveland Clinic, Cleveland, OH, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Deutsche Gesellschaft für Pädiatrische Kardiologie e.V., Düsseldorf, Germany, ⁵National Register for Congenital Heart Defects, Berlin, Germany, ⁶Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Heart Failure, Cardiovascular, Diagnosis/Prevention, Heart, Heart Failure, MR Value, Valves

Motivation: Ventriculo-arterial coupling ratio (VAC) is useful to assess the relationship between ventricle performance and the arterial system and may be estimated non-invasively using CMR.

Goal(s): Our goal was to determine if the non-invasive VAC (nVAC) was accurate in patients with repaired Tetralogy of Fallot and if it predicts outcomes.

Approach: We compared the CMR-derived right and left ventricular (RV and LV) nVAC with invasive VAC, and separately compared nVAC with outcomes in large clinical registries.

Results: CMR provides an accurate estimate of nVAC. Patients with events had a significantly higher RV and LV nVAC than those without events.

Impact: CMR-derived Ventriculo-Arterial Coupling (VAC) ratio accurately reflects the invasively derived VAC and may be used as an indicator for possible future cardiac events and therefore improve risk stratification in patients with repaired Tetralogy of Fallot.

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