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Abstract #3681

Cardiac Motion-Resolved 3D Whole-Heart Myocardial T2* Mapping Reveals Diminished Cyclic Response in Hypertrophic Cardiomyopathy at 1.5T

Yuheng Huang1,2, Chun-Ho Yun3, Xingmin Guan1, Li-Ting Huang4, Shahriar Shalikar5, Florian Rader6, Mohammad Ahmed ZakiAl-Ani7, Janet Wei6, Alan Kwan6, Christopher Nguyen8, Xiaoming Bi9, Debiao Li4, Thoralf Niendorf 5, Min-Chi Ku5, Rohan Dharmakumar1, and Hsin-Jung Yang4
1krannert cardiovascular research center, Indiana University School of Medicine, Indianapolis, IN, United States, 2Bioengineering, UCLA, LA, CA, United States, 3Mackay Memorial Hospital, Taipei, Taiwan, 4Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, LA, CA, United States, 5Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, 6Cardiology, Cedars-Sinai Medical Center, LA, CA, United States, 7Cardiology, University of Florida, Gainesville, FL, United States, 8Cardiovascular Innovation Research Center (CIRC), Cleveland Clinic, Cleveland, OH, United States, 9Siemens Healthineers, LA, LA, United States

Synopsis

Keywords: Myocardium, Heart, Hypertrophic cardiomyopathy (HCM); Tissue Characterization

Motivation: Hypertrophic cardiomyopathy (HCM) is a prevalent cardiac disorder associated with an increased risk of heart failure and sudden cardiac death.

Goal(s): Detecting myocardial tissue alterations in hypertrophic hearts is important for early intervention and management.

Approach: In this study, we employed a 3D, motion-resolved, free-breathing, non-ECG-gated mGRE sequence at 1.5T to examine T2* sensitized changes across the cardiac cycle in normal subjects and in HCM patients.

Results: Our findings demonstrate T2* fluctuation across the cardiac cycle reduced significantly in HCM patients compared to healthy controls, suggesting the potential sensitivity of cyclic myocardial T2* in identifying myocardial abnormality.

Impact: This study applied a free-breathing, cardiac-phase-resolved whole-heart T2* mapping technique for assessing T2*variations across the cardiac cycle. Although additional validation is needed, our early findings demonstrate the approach's potential to assess changes in myocardial oxygenation impairments associated with hypertrophic cardiomyopathy.

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Abstract

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