Keywords: Vessels, Fat and Fat/Water Separation, lymphatics
Motivation: Lymphedema is the accumulation of interstitial fluid in soft tissues and affects approximately 140–200 million worldwide. There is currently a paucity of lymphedema studies that validate gene expression data with MR data.
Goal(s): The purpose of our study was to correlate regional adipose gene expression from RNA sequencing with MR-derived features such as fat volume, fluid volume, fat fraction and total subcutaneous area.
Approach: This IRB-approved retrospective study in patients with extremity lymphedema correlated MR findings from the affected and contralateral unaffected extremity with RNA sequencing.
Results: Our results integrate RNA sequencing data and MR imaging analyses to differentiate lymphedema from normal tissue.
Impact: Future applications will evaluate these gene expression patterns and imaging features, including radiomics, in cases of early/equivocal lymphedema to assess gene changes that correlate with duration/severity of disease to provide insight into the natural history and pathophysiology of lymphedema.
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