Abstract #3690

Pushing the Limits of ASL Spatiotemporal Resolution using 3D Accelerated Stack-of-Spirals

Ludwig Sichen Zhao¹, Yuling Chang², Ze Wang³, Jay A Gottfried^4,5, M. Dylan Tisdall⁶, John A Detre^4,6, and Manuel Taso²

¹Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, ²Siemens Medical Solutions USA Inc, Malvern, PA, United States, ³Department of Diagnostic Radiology and Nuclear Medicine, School of Medicine, University of Maryland, Baltimore, MD, United States, ⁴Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Psychology, School of Arts and Science, University of Pennsylvania, Philadelphia, PA, United States, ⁶Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling

Motivation: ASL provides a quantitative biomarker of regional brain function and vascular integrity. However, current ASL methods remain hampered by trade-offs in spatial and temporal resolution.

Goal(s): Improve the spatiotemporal resolution of ASL through optimized acceleration.

Approach: Pseudocontinuous ASL with Stack-of-Spirals 3D TSE readouts were accelerated with ESPRiT compressed-sensing and imaging reconstruction and tested in healthy subjects.

Results: Image resolution and quality comparable to highly segmented acquisitions were achieved using single- or two-shot acquisitions across all brain regions, including high-susceptibility regions.

Impact: Improved spatial and temporal resolution enables enhanced applications including ASL-based resting-state or task dynamics in high-susceptibility regions.

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