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Abstract #3693

Effect of Saturation on Velocity-Selective Arterial Spin Labeling based Perfusion Quantification: Accounting for the Inflow of Fresh Blood

Feng Xu1,2, Dan Zhu1,2, Dapeng Liu1,2, and Qin Qin1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Perfusion, Cerebral Blood Flow

Motivation: For velocity-selective arterial spin labeling (VSASL), a scaling factor (SIB) was recommended to correct the saturation recovery of arterial blood right before labeling. However, the SIB value needs to consider the inflow effect.

Goal(s): To account for the inflow of fresh, unsaturated spins due to the limited coverage of the transmit body coil into VSASL-based CBF quantification.

Approach: The SIB was measured using none-selective and slab-selective saturation with varied saturation times, respectively.

Results: Slab-selective saturation with a 2.0s delay yielded optimal tSNR efficiency and SIB=0.90 provided more accurate CBF estimation than a simple saturation recovery model.

Impact: To account for inflow effects, VSASL-based CBF quantification should use a slab-selective saturation with a 2.0s delay for optimal tSNR efficiency, and apply a scaling factor of 0.90 for more accurate CBF estimation than relying on the saturation recovery model.

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Keywords