Keywords: fMRI Analysis, fMRI Analysis, 7 T MRI, Glymphatic system, cerebrospinal fluid, Blood flow, coupling
Motivation: By investigating the coupling between cerebrovascular activity and CSF flow using 7T, we aim to develop innovative imaging biomarkers for neurological-disorders.
Goal(s): To explore the relationship between BOLD and CSF flow dynamics and identify potential biomarkers for neurological-disorders at 7T.
Approach: 66 volunteers` functional and structural data were acquired on a 7T-scanner. Group-level-ICA was employed to generate five networks. To investigate the blood and CSF flow coupling, BOLD-CSF cross-correlation was performed.
Results: No significant relative between BOLD-CSF coupling and age. Difference had existed in AAL2 vs AUD for BOLD-CSF coupling, and AAL2 vs AUD, SMN, VIS, AUD vs CEN, DMN for -d/dt(BOLD)-CSF coupling.
Impact: This study will not only help us understand the intricate relationship between blood flow and CSF dynamics and potentially identify novel biomarkers neurodegenerative diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords