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Abstract #3708

The Coupling of Cerebrovascular Activity and Cerebrospinal Fluid Flow: A Pioneering Study at 7 T MRI

Pin Lv1, Jonathon J Parker2, Justin Cramer1, Ichiro Ikuta1, and Yuxiang Zhou1
1Radiology, Mayo Clinic, Phoenix, AZ, United States, 2Neurosurgery, Mayo Clinic, Phoenix, AZ, United States

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, 7 T MRI, Glymphatic system, cerebrospinal fluid, Blood flow, coupling

Motivation: By investigating the coupling between cerebrovascular activity and CSF flow using 7T, we aim to develop innovative imaging biomarkers for neurological-disorders.

Goal(s): To explore the relationship between BOLD and CSF flow dynamics and identify potential biomarkers for neurological-disorders at 7T.

Approach: 66 volunteers` functional and structural data were acquired on a 7T-scanner. Group-level-ICA was employed to generate five networks. To investigate the blood and CSF flow coupling, BOLD-CSF cross-correlation was performed.

Results: No significant relative between BOLD-CSF coupling and age. Difference had existed in AAL2 vs AUD for BOLD-CSF coupling, and AAL2 vs AUD, SMN, VIS, AUD vs CEN, DMN for -d/dt(BOLD)-CSF coupling.

Impact: This study will not only help us understand the intricate relationship between blood flow and CSF dynamics and potentially identify novel biomarkers neurodegenerative diseases.

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Keywords