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Abstract #3710

Neurovascular Uncoupling in Mild Cognitive Impairment: Insights from Multiband Multi-echo BOLD-Perfusion Imaging

Alexander D. Cohen1, Laura Glass Umfleet2, Malgorzata Franczak2, Suchandrima Banerjee3, Brice Fernandez4, Kelly Ristow1, and Yang Wang1
1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, 3GE Healthcare, Menlo Park, CA, United States, 4GE Healthcare, Buc, France

Synopsis

Keywords: fMRI Analysis, Neurodegeneration, Neurovascular Uncoupling, Artierial Spin Labeling, BOLD, resting state

Motivation: Neurovascular uncoupling (NVU) is increasingly recognized as a critical pathophysiological driver of cognitive decline in the progression of Alzheimer's Disease (AD). Recently developed imaging techniques allow NVU to be non-invasively estimated.

Goal(s): Is resting state BOLD-CBF coupling, measured with multiband, multi-echo (MBME) simultaneous BOLD/ASL imaging, altered in individuals with mild cognitive impairment.

Approach: BOLD and perfusion-weighted (PW) signals were correlated with each other and the correlation was compared between age and sex-matched control subjects on a vocelwise basis.

Results: BOLD-CBF coupling was signficantly lower for the MCI group compared the control group in the precuneus, visual cortex, and middle frontal gyrus.

Impact: Resting state BOLD-CBF coupling was lower in MCI individuals compared to age and sex matched control individuals. These results reveal a fundamental disruption in brain-blood flow dynamics in MCI. The physiological underpinnings of these results warrant further investigation.

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Keywords