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Abstract #3722

Brainstem Functional Mapping During Motor Tasks with Ultra-High Field MRI

Yifei Sun1,2, Dolores Huang2,3, Luke Henderson2,3, Paul Austin2,3, Fernando Calamante1,2,4, YuHong Fu2,3,5, and Jinglei Lv1,2,5
1School of Biomedical Engineering, University of Sydney, Sydney, Australia, 2Brain and Mind Center, University of Sydney, Sydney, Australia, 3School of Medical Sciences, University of Sydney, Sydney, Australia, 4Sydney Imaging, University of Sydney, Sydney, Australia, 5Joint Last Author, Sydney, Australia

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based), Human Brainstem Functional Mapping

Motivation: Parkinson’s disease (PD) affects the brainstem, leading to motor symptoms that impact patients’ quality of life. Understanding brainstem activation in motor tasks could provide insights into early markers of PD.

Goal(s): We aim to identify specific brainstem functional activations during distinct motor tasks using functional resonance imaging (fMRI).

Approach: Using a general linear model, we analysed task fMRI data from 28 healthy subjects performing foot, tongue, and wrist movements.

Results: Our findings revealed task-specific activation patterns in brainstem regions, highlighting differential involvement across different motor functions. This work enhances our understanding of brainstem activity in motor control, offering insights relevant to neurodegenerative conditions.

Impact: Understanding brainstem motor function may reveal early markers of Parkinson’s disease, bridging the gap between molecular pathology and detectable brain functional changes. This could advance early diagnosis and deepen insights into PD-related neurodegeneration in motor pathways.

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