Keywords: Task/Intervention Based fMRI, fMRI (task based)
Motivation: To establish precise measurements that directly reflect neuronal activity, it is necessary to re-evaluate the current fMRI method.
Goal(s): Evaluating the effectiveness of diffusion fMRI and its spatial specificity relative to BOLD-fMRI, with consideration of diffusion changes and perfusion effects.
Approach: Utilized dfMRI with six MPG directions to obtain mean diffusivity and apparent diffusion coefficients and to suppress the perfusion effect.
Results: dfMRI with six MPG directions could provide more localized activation mapping, with diffusion-driven signal changes potentially influenced by neuronal activity-related water transport mechanisms.
Impact: dfMRI with multiple MPG directions enables more localized brain activity mapping compared to BOLD-fMRI, suggesting that water transport related to neuronal activity may contribute to pseudo-diffusion effects in diffusion MRI signals.
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