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Abstract #3733

A comparative analysis of single-echo and multi-echo EPI sequences for task-fMRI

Alice Giubergia1,2, Giulio Ferrazzi3, Marco Castellaro2, Sara Mascheretti4,5, Valentina Lampis4,5, Florian Montano6, Alessandra Bertoldo2, Tommaso Ciceri1, and Denis Peruzzo1
1Neuroimaging Unit, IRCCS "Eugenio Medea", Bosisio Parini (LC), Italy, 2Department of Information Engineering, University of Padova, Padova, Italy, 3Philips Healthcare, Milano (MI), Italy, 4Department of Brain and Behavioral Sciences, University of Pavia, Pavia (PV), Italy, 5Child Psychopathology Unit, IRCCS "Eugenio Medea", Bosisio Parini (LC), Italy, 6Radiology & Neuroradiology Unit, IRCCS "Eugenio Medea", Bosisio Parini (LC), Italy

Synopsis

Keywords: fMRI Analysis, fMRI (task based)

Motivation: Multi-Echo (ME) fMRI technique during task has shown to enhance BOLD sensitivity when compared with single-echo data derived from ME itself (Echo-2).

Goal(s): Investigate the perks of a ME protocol with a comprehensive comparison with an Optimized Single-Echo (OSE) acquisition (i.e. not with data derived from ME itself).

Approach: We characterized 3 datasets (ME, OSE, Echo-2) computing single-subject and group-level analyses, performance metrics and fMRI reliability.

Results: ME and OSE showed better results than Echo-2 confirming previous studies, but in a comparison of optimized sequences, the superior performance of ME is not confirmed.

Impact: A comprehensive comparison of Multi-Echo fMRI with an Optimized Single-Echo (OSE) acquisition (i.e. not with data derived from ME itself) enables a direct evaluation of two different acquisition approaches at their best performances.

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Keywords