Abstract #3737

Diffusion MRI of white matter lesion dynamics in progressive multiple sclerosis

Jordan A. Chad^1,2, Julia Rybkina³, Tania Bruno^4,5, Brenda Colella³, Robin Green^3,6, and Asaf Gilboa^1,7

¹Rotman Research Institute, Baycrest Academy for Research and Education, Toronto, ON, Canada, ²Department of Radiology, University of Calgary, Calgary, AB, Canada, ³KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, ON, Canada, ⁴Division of Physical Medicine and Rehabilitation, Toronto Rehabilitation Institute-University Health Network, Toronto, ON, Canada, ⁵Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁶Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁷Department of Psychology, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: It is unclear how white matter lesions evolve during the progressive stage of multiple sclerosis (MS).

Goal(s): To measure four-month change in diffusion metrics within lesions of progressive MS patients.

Approach: We compare diffusion changes within the lesions with those in the normal-appearing white matter (NAWM).

Results: Diffusion metrics in the lesions generally follow opposite trajectories to those in the NAWM, often with greater magnitude.

Impact: This work indicates that it may be desirable to monitor the progressive stage of MS by assessing diffusion changes within white matter lesions, rather than merely within the NAWM as is customary.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.