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Abstract #3740

Water Content, T1 relaxation and Diffusion MRI Correlates of Antiphospholipid Antibodies in Primary Progressive Multiple Sclerosis

Noah Marini1,2, Kaya Frese3, Pal Patel3, Pierre Becquart3, Anthony Traboulsee4,5, Robert Carruthers4, Shannon Kolind1,2,4,5,6, Alice Shabas4, Ana-Luiza Sayao4, Virginia Devonshire4, Roger Tam1,5,7, Wayne Moore2,3,4, David Li1,4,5, Jacqueline Quandt2,3,4, Irene Vavasour1,2, and Cornelia Laule1,2,3,6
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 3Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 4Medicine, University of British Columbia, Vancouver, BC, Canada, 5MSMRI Research Group, University of British Columbia, Vancouver, BC, Canada, 6Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 7School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, brain, primary progressive MS, antiphospholipid antibodies, water content, T1, fibre fraction, myelin, axons

Motivation: Antiphospholipid antibodies (aPLA) target the phospholipid bilayer of cell membranes. Understanding the relationship between advanced MRI metrics and aPLA may assist in establishing imaging biomarkers for PPMS.

Goal(s): To assess aPLA associations with MRI-derived water content, T1 relaxation, and diffusion metrics in PPMS and RRMS lesions and normal appearing white matter (NAWM).

Approach: 20 PPMS and 33 RRMS participants underwent 3T MRI and same-day venous blood sampling for IgM/IgG aPLA.

Results: Specific aPLA, including IgM-sphingomyelin, were correlated with NAWM water content and T1 relaxation, as well as lesion tissue fibre fraction, non-restricted fraction, radial diffusivity, and restricted fraction in PPMS, but not RRMS.

Impact: Biological immune factors that impact MRI metrics may change depending on the subtype of MS being imaged. It is possible that the specificity of advanced MRI varies across MS phenotypes and further investigation is warranted.

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Abstract

Keywords